Relative contents and concomitant release of prodynorphin/neoendorphin-derived peptides in rat hippocampus.

@article{Chavkin1983RelativeCA,
  title={Relative contents and concomitant release of prodynorphin/neoendorphin-derived peptides in rat hippocampus.},
  author={Charles Chavkin and Cyrus E. Bakhit and Eckard Weber and Floyd E. Bloom},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1983},
  volume={80 24},
  pages={7669-73}
}
The contents and molecular forms of five different prodynorphin-derived opioid peptides were compared in extracts of rat hippocampus by radioimmunoassay after C18-HPLC resolution. Dynorphin (Dyn) A(1-17) immunoreactivity (ir) and Dyn B-ir were heterogeneous in form; Dyn A(1-8)-ir, alpha-neoendorphin (alpha neo)-ir and beta-neoendorphin (beta neo)-ir each eluted as single homogeneous peaks of immunoreactivity. The fraction of immunoreactivity having the same retention as the appropriate… CONTINUE READING