Relative changes in the function of muscle ribosomes and mitochondria during the early phase of steroid-induced catabolism.

@article{Bullock1972RelativeCI,
  title={Relative changes in the function of muscle ribosomes and mitochondria during the early phase of steroid-induced catabolism.},
  author={Gillian R. Bullock and E E. Carter and Peter Elliott and Roel Peters and Peter A. Simpson and A. M. White},
  journal={The Biochemical journal},
  year={1972},
  volume={127 5},
  pages={881-92}
}
1. Five glucocorticoids, when administered daily to rats for 5-7 days at a dosage of 5mg/kg, were in the following order of effectiveness with respect to their ability to decrease the weight gain of whole animals and the vastus lateralis, vastus medialis and gluteus medius muscles: corticosterone<prednisolone<triamcinolone <betamethasone<dexamethasone<triamcinolone acetonide. 2. The low catabolic potencies of corticosterone and prednisolone were reflected in the high doses (20mg/kg) required to… CONTINUE READING
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