Relative bioavailability estimation of carbamazepine crystal forms using an artificial stomach-duodenum model.

Abstract

The in vitro dissolution of carbamazepine (CBZ) was investigated using an automated artificial stomach-duodenum (ASD) model. Successful simulation of the dog physiology in the fasted state showed that the rank order of the ASD estimated bioavailabilities is as follows: Form III > Form I > dihydrate. This result is in excellent agreement with those found in literature. Additional simulations comparing different gastric transit times during fasted and fed states are also discussed.

010020020102011201220132014201520162017
Citations per Year

419 Citations

Semantic Scholar estimates that this publication has 419 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Carino2006RelativeBE, title={Relative bioavailability estimation of carbamazepine crystal forms using an artificial stomach-duodenum model.}, author={Stephen R Carino and David C. Sperry and Michael Hawley}, journal={Journal of pharmaceutical sciences}, year={2006}, volume={95 1}, pages={116-25} }