Relative atrophy of the flocculus and ocular motor dysfunction in SCA2 and SCA6.

@article{Ying2005RelativeAO,
  title={Relative atrophy of the flocculus and ocular motor dysfunction in SCA2 and SCA6.},
  author={Sarah H. Ying and Soo In Choi and M Lee and Susan L. Perlman and Robert W. Baloh and Arthur W. Toga and David S. Zee},
  journal={Annals of the New York Academy of Sciences},
  year={2005},
  volume={1039},
  pages={430-5}
}
Two hereditary ataxia syndromes show distinct profiles of region-specific atrophy and ocular motor deficits. Selective pontine atrophy is associated with slowed saccades in ataxin-2 mutations, and selective floccular atrophy is associated with impaired pursuit and gaze-holding abnormalities in Ca(V)2.1 mutations. Although the flocculus seems to be spared relative to the pons in ataxin-2 mutations, and pursuit and gaze-holding appear to be relatively normal, these can be difficult to assess at… CONTINUE READING