Relative and absolute bioavailability of prednisone and prednisolone after separate oral and intravenous doses.

@article{Ferry1988RelativeAA,
  title={Relative and absolute bioavailability of prednisone and prednisolone after separate oral and intravenous doses.},
  author={James J. Ferry and A M Horvath and Ihor Bekersky and Edward C. Heath and C. Frank Ryan and Wayne A. Colburn},
  journal={Journal of clinical pharmacology},
  year={1988},
  volume={28 1},
  pages={81-7}
}
A randomized, four-way cross-over study was conducted in eight healthy male volunteers to determine the relative and absolute bioavailability of prednisone (PN) and prednisolone (PL). PN and PL were administered as single, oral 10-mg tablet doses and as 10-mg zero-order 0.5-hour intravenous infusions. Comparable mean PN and PL maximum plasma concentrations (Cmax), times for Cmax, areas under the plasma concentration-time curves (AUC), and apparent elimination rate constants between tablet… CONTINUE READING

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