Relative affinities of dopaminergic drugs at dopamine D2 and D3 receptors.

@article{Levant1995RelativeAO,
  title={Relative affinities of dopaminergic drugs at dopamine D2 and D3 receptors.},
  author={Beth Levant and D. G. E. Grigoriadis and Errol B De Souza},
  journal={European journal of pharmacology},
  year={1995},
  volume={278 3},
  pages={243-7}
}
Quantitative autoradiography was used to evaluate the pharmacological profile of dopamine D2-like receptors labeled by [125I]iodosulpiride. Caudate/putamen, a brain region associated primarily with dopamine D2 receptor mRNA, was used as a prototypical D2 tissue; cerebellar lobule X (D3 mRNA associated), as a D3 tissue. 7-OH-DPAT ((+/-)-2-dipropylamino-7-hydroxy-1,2,3,4- tetrahydronaphthalene) exhibited selectively for cerebellar receptors (24-fold), followed by quinpirole (6-fold). Haloperidol… CONTINUE READING
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