Relative abuse liability of triazolam: Experimental assessment in animals and humans

@article{Griffiths1985RelativeAL,
  title={Relative abuse liability of triazolam: Experimental assessment in animals and humans},
  author={R. Griffiths and R. Lamb and N. Ator and J. Roache and J. Brady},
  journal={Neuroscience \& Biobehavioral Reviews},
  year={1985},
  volume={9},
  pages={133-151}
}
The abuse liability of a drug is a positive, interactive function of the reinforcing and adverse effects of the drug. The relative abuse liability of the hypnotic benzodiazepine, triazolam, has been controversial. This paper reviews animal and human studies bearing on its relative abuse liability, including data on pharmacological profile, reinforcing effects, liking, speed of onset, discriminative stimulus effects, subjective effects, physiological dependence, rebound and early morning… Expand
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Abuse liability of triazolam: experimental measurements in animals and humans.
Drug abuse liability refers to: (a) the liability for abuse (i.e., the likelihood that a drug will be abused) and/or (b) the liability of abuse (i.e., the untoward effects of abusing the drug). These… Expand
Relative Abuse Liability of GHB in Humans: A Comparison of Psychomotor, Subjective, and Cognitive Effects of Supratherapeutic Doses of Triazolam, Pentobarbital, and GHB
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The profile of effects of GHB only partially overlaps with that of triazolam and pentobarbital, and the possibility of accidental overdose with GHB appears to be greater than with other sedative/hypnotic drugs. Expand
Relative Abuse Liability of Indiplon and Triazolam in Humans: A Comparison of Psychomotor, Subjective, and Cognitive Effects
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The data suggest that although the abuse potential of indiplon is not different from that of triazolam at these doses, psychomotor and cognitive impairment after large doses ofIndiplon might be less. Expand
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Overall, the experimental literature does not support the widely held belief that alprazolam's abuse liability is greater than that of other benzodiazepines, but much more research is needed. Expand
Abuse Liability of Benzodiazepines: A Review of Human Studies Evaluating Subjective and/or Reinforcing Effects
This chapter reviews human experiments pertinent to the abuse liability of benzodiazepines. These studies assess subjective and/or reinforcing effects in subjects with histories of drug abuse (Table… Expand
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A current review of various problems that have been identified with the long-term use and the recreational abuse of benzodiazepines, including memory impairment, risk of accidents, falls and hip fractures in the elderly, a withdrawal syndrome, brain damage, overuse inThe elderly, over use by chronic pain patients, overused by alcoholics and recreational abuse among alcoholic and polydrug abusers are provided. Expand
Behavioral Pharmacology of Zolpidem Relative to Benzodiazepines A Review
  • C. R. Rush
  • Medicine, Psychology
  • Pharmacology Biochemistry and Behavior
  • 1998
TLDR
The most parsimonious conclusion is that despite its unique neuropharmacological profile, the behavioral effects of zolpidem are generally similar to those of benzodiazepines. Expand
Behavioral Pharmacology of Sedatives, Hypnotics, and Anxiolytics
TLDR
This chapter reviews the behavioral pharmacology and abuse liability of two nonbenzodiazepine compounds marketed for the treatment of anxiety and sleep disorders: buspirone and zolpidem, respectively. Expand
Clinical Pharmacokinetics of Non-Opiate Abused Drugs
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The clinical significance of kinetic characteristics with respect to abuse is discussed where possible and the pharmacokinetic properties that presumably contribute to self-administration and drug abuse include rapid delivery of the drug into the central nervous system and high free drug clearance. Expand
Principles of drug abuse liability assessment in laboratory animals.
TLDR
The rationale for use of preclinical assessments of abuse liability in laboratory animals is described, and "cross-cutting" methodological issues that apply to behavioral evaluations intended to contribute to an abuse liability evaluation package are discussed. Expand
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