Relative abuse liability of triazolam: Experimental assessment in animals and humans
@article{Griffiths1985RelativeAL, title={Relative abuse liability of triazolam: Experimental assessment in animals and humans}, author={Roland R. Griffiths and Richard J Lamb and Nancy A. Ator and John D Roache and Joseph V. Brady}, journal={Neuroscience \& Biobehavioral Reviews}, year={1985}, volume={9}, pages={133-151} }
75 Citations
Abuse liability of triazolam: experimental measurements in animals and humans.
- PsychologyPsychopharmacology series
- 1987
Drug abuse liability refers to: (a) the liability for abuse (i.e., the likelihood that a drug will be abused) and/or (b) the liability of abuse (i.e., the untoward effects of abusing the drug). These…
Relative Abuse Liability of GHB in Humans: A Comparison of Psychomotor, Subjective, and Cognitive Effects of Supratherapeutic Doses of Triazolam, Pentobarbital, and GHB
- PsychologyNeuropsychopharmacology
- 2006
The profile of effects of GHB only partially overlaps with that of triazolam and pentobarbital, and the possibility of accidental overdose with GHB appears to be greater than with other sedative/hypnotic drugs.
Relative Abuse Liability of Indiplon and Triazolam in Humans: A Comparison of Psychomotor, Subjective, and Cognitive Effects
- PsychologyJournal of Pharmacology and Experimental Therapeutics
- 2007
The data suggest that although the abuse potential of indiplon is not different from that of triazolam at these doses, psychomotor and cognitive impairment after large doses ofIndiplon might be less.
Abuse liability of alprazolam relative to other commonly used benzodiazepines: A review
- PsychologyNeuroscience & Biobehavioral Reviews
- 1993
Abuse Liability of Benzodiazepines: A Review of Human Studies Evaluating Subjective and/or Reinforcing Effects
- Psychology
- 1985
This chapter reviews human experiments pertinent to the abuse liability of benzodiazepines. These studies assess subjective and/or reinforcing effects in subjects with histories of drug abuse (Table…
Benzodiazepine self-administration in humans and laboratory animals – implications for problems of long-term use and abuse
- Psychology, MedicinePsychopharmacology
- 1997
A current review of various problems that have been identified with the long-term use and the recreational abuse of benzodiazepines, including memory impairment, risk of accidents, falls and hip fractures in the elderly, a withdrawal syndrome, brain damage, overuse inThe elderly, over use by chronic pain patients, overused by alcoholics and recreational abuse among alcoholic and polydrug abusers are provided.
Behavioral Pharmacology of Zolpidem Relative to Benzodiazepines A Review
- Psychology, BiologyPharmacology Biochemistry and Behavior
- 1998
Behavioral Pharmacology of Sedatives, Hypnotics, and Anxiolytics
- Psychology, Biology
- 1998
This chapter reviews the behavioral pharmacology and abuse liability of two nonbenzodiazepine compounds marketed for the treatment of anxiety and sleep disorders: buspirone and zolpidem, respectively.
Clinical Pharmacokinetics of Non-Opiate Abused Drugs
- Biology, PsychologyClinical pharmacokinetics
- 1989
The clinical significance of kinetic characteristics with respect to abuse is discussed where possible and the pharmacokinetic properties that presumably contribute to self-administration and drug abuse include rapid delivery of the drug into the central nervous system and high free drug clearance.
Principles of drug abuse liability assessment in laboratory animals.
- PsychologyDrug and alcohol dependence
- 2003
References
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This chapter reviews human experiments pertinent to the abuse liability of benzodiazepines. These studies assess subjective and/or reinforcing effects in subjects with histories of drug abuse (Table…
Differential effects of diazepam and pentobarbital on mood and behavior.
- Psychology, MedicineArchives of general psychiatry
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The diazepam-produced deterioration in mood and social behavior was a subtle effect observed in a population for which usual therapeutic indications were lacking and at higher than usual therapeutic doses, and warrants clinical awareness in monitoring the course of treatment.
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Dependence liability of 10 drugs was tested in rhesus monkeys and benzoctamine and perlapine were found to be dependence-free drugs.
Reinforcing properties of stereoisomers of the putative sigma agonists N-allylnormetazocine and cyclazocine in rhesus monkeys.
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Reinforcing doses of the three compounds resulted in injections evenly distributed across the 60-min session in a pattern similar to cocaine self-administration, whereas the racemic mixtures and the (-)-isomers produced negatively accelerated patterns of injections which resembled typical saline patterns of extinction responding.
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Ashton's careful study is the latest of several investigations that have shown quite unequivocally that benzodiazepines may produce pharmacological dependence in therapeutic dosage, and stems from the early symptoms of withdrawal being those of anxiety, so that when a patient becomes anxious after withdrawal of benzdiazepines this may be mistaken simply for a return of pre-existing anxiety.
Comparison of the reinforcing properties of zopiclone and triazolam in former alcoholics.
- MedicinePharmacology
- 1983
Zopiclone, like triazolam, may induce some feelings similar to those obtained with alcohol, and there was a difference in patients' drug preference for trizolam in comparison to zopicl one.
Opioids: Similarity between evaluations of subjective effects and animal self‐administration results
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Good concordance between the human and animal results further validates each procedure and suggests the possibility that both thehuman and animal procedures are measuring a common underlying pharmacological property which relates to abuse potential of drugs.
Demonstration of tolerance to and physical dependence of N-allylnormorphine (nalorphine).
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The studies provide additional support for the hypothesis that the narcotic antagonists produce a type of physical dependence that is qualitatively different from that produced by the narcotics analgesics.
Pharmacology and Hypnotic Efficacy of Triazolam
- PsychologyPharmacotherapy
- 1983
Overall, triazolam is an effective and safe compound for the symptomatic treatment of insomnia complaints, making it the shortest acting benzodiazepine available in the United States.
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The self-administration data and data describing the subjective and cardiovascular spectrum of action were combined to yield a more complete profile of cocaine's action in humans.