Relative abuse liability of triazolam: Experimental assessment in animals and humans

@article{Griffiths1985RelativeAL,
  title={Relative abuse liability of triazolam: Experimental assessment in animals and humans},
  author={Roland R. Griffiths and Richard J Lamb and Nancy A. Ator and John D Roache and Joseph V. Brady},
  journal={Neuroscience \& Biobehavioral Reviews},
  year={1985},
  volume={9},
  pages={133-151}
}

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References

SHOWING 1-10 OF 165 REFERENCES
Abuse Liability of Benzodiazepines: A Review of Human Studies Evaluating Subjective and/or Reinforcing Effects
This chapter reviews human experiments pertinent to the abuse liability of benzodiazepines. These studies assess subjective and/or reinforcing effects in subjects with histories of drug abuse (Table
Differential effects of diazepam and pentobarbital on mood and behavior.
TLDR
The diazepam-produced deterioration in mood and social behavior was a subtle effect observed in a population for which usual therapeutic indications were lacking and at higher than usual therapeutic doses, and warrants clinical awareness in monitoring the course of treatment.
Dependence liability of several sedative-hypnotic agents evaluated in monkeys.
TLDR
Dependence liability of 10 drugs was tested in rhesus monkeys and benzoctamine and perlapine were found to be dependence-free drugs.
Reinforcing properties of stereoisomers of the putative sigma agonists N-allylnormetazocine and cyclazocine in rhesus monkeys.
  • B. Slifer, R. Balster
  • Biology, Psychology
    The Journal of pharmacology and experimental therapeutics
  • 1983
TLDR
Reinforcing doses of the three compounds resulted in injections evenly distributed across the 60-min session in a pattern similar to cocaine self-administration, whereas the racemic mixtures and the (-)-isomers produced negatively accelerated patterns of injections which resembled typical saline patterns of extinction responding.
Benzodiazepines on trial.
  • P. Tyrer
  • Psychology, Medicine
    British medical journal
  • 1984
TLDR
Ashton's careful study is the latest of several investigations that have shown quite unequivocally that benzodiazepines may produce pharmacological dependence in therapeutic dosage, and stems from the early symptoms of withdrawal being those of anxiety, so that when a patient becomes anxious after withdrawal of benzdiazepines this may be mistaken simply for a return of pre-existing anxiety.
Comparison of the reinforcing properties of zopiclone and triazolam in former alcoholics.
TLDR
Zopiclone, like triazolam, may induce some feelings similar to those obtained with alcohol, and there was a difference in patients' drug preference for trizolam in comparison to zopicl one.
Opioids: Similarity between evaluations of subjective effects and animal self‐administration results
TLDR
Good concordance between the human and animal results further validates each procedure and suggests the possibility that both thehuman and animal procedures are measuring a common underlying pharmacological property which relates to abuse potential of drugs.
Demonstration of tolerance to and physical dependence of N-allylnormorphine (nalorphine).
TLDR
The studies provide additional support for the hypothesis that the narcotic antagonists produce a type of physical dependence that is qualitatively different from that produced by the narcotics analgesics.
Pharmacology and Hypnotic Efficacy of Triazolam
TLDR
Overall, triazolam is an effective and safe compound for the symptomatic treatment of insomnia complaints, making it the shortest acting benzodiazepine available in the United States.
Cocaine self-administration in humans.
TLDR
The self-administration data and data describing the subjective and cardiovascular spectrum of action were combined to yield a more complete profile of cocaine's action in humans.
...
...