Relative abuse liability of triazolam: Experimental assessment in animals and humans

@article{Griffiths1985RelativeAL,
  title={Relative abuse liability of triazolam: Experimental assessment in animals and humans},
  author={R. Griffiths and R. Lamb and N. Ator and J. Roache and J. Brady},
  journal={Neuroscience \& Biobehavioral Reviews},
  year={1985},
  volume={9},
  pages={133-151}
}
The abuse liability of a drug is a positive, interactive function of the reinforcing and adverse effects of the drug. The relative abuse liability of the hypnotic benzodiazepine, triazolam, has been controversial. This paper reviews animal and human studies bearing on its relative abuse liability, including data on pharmacological profile, reinforcing effects, liking, speed of onset, discriminative stimulus effects, subjective effects, physiological dependence, rebound and early morning… Expand
Abuse liability of triazolam: experimental measurements in animals and humans.
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References

SHOWING 1-10 OF 167 REFERENCES
Abuse Liability of Benzodiazepines: A Review of Human Studies Evaluating Subjective and/or Reinforcing Effects
This chapter reviews human experiments pertinent to the abuse liability of benzodiazepines. These studies assess subjective and/or reinforcing effects in subjects with histories of drug abuse (TableExpand
Differential effects of diazepam and pentobarbital on mood and behavior.
TLDR
The diazepam-produced deterioration in mood and social behavior was a subtle effect observed in a population for which usual therapeutic indications were lacking and at higher than usual therapeutic doses, and warrants clinical awareness in monitoring the course of treatment. Expand
Dependence liability of several sedative-hypnotic agents evaluated in monkeys.
TLDR
Dependence liability of 10 drugs was tested in rhesus monkeys and benzoctamine and perlapine were found to be dependence-free drugs. Expand
Comparison of diazepam and oxazepam: preference, liking and extent of abuse.
TLDR
Previous experimental observations suggesting that diazepam has a higher abuse liability than oxazepam are extended, compatible with an analysis of epidemiological data showing thatdiazepam abuse uniformly exceeds oxzepam abuse on seven epidemiological measures of drug abuse. Expand
Reinforcing properties of stereoisomers of the putative sigma agonists N-allylnormetazocine and cyclazocine in rhesus monkeys.
  • B. Slifer, R. Balster
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental therapeutics
  • 1983
TLDR
Reinforcing doses of the three compounds resulted in injections evenly distributed across the 60-min session in a pattern similar to cocaine self-administration, whereas the racemic mixtures and the (-)-isomers produced negatively accelerated patterns of injections which resembled typical saline patterns of extinction responding. Expand
Benzodiazepines on trial.
  • P. Tyrer
  • Medicine
  • British medical journal
  • 1984
TLDR
Ashton's careful study is the latest of several investigations that have shown quite unequivocally that benzodiazepines may produce pharmacological dependence in therapeutic dosage, and stems from the early symptoms of withdrawal being those of anxiety, so that when a patient becomes anxious after withdrawal of benzdiazepines this may be mistaken simply for a return of pre-existing anxiety. Expand
Comparison of the reinforcing properties of zopiclone and triazolam in former alcoholics.
TLDR
Zopiclone, like triazolam, may induce some feelings similar to those obtained with alcohol, and there was a difference in patients' drug preference for trizolam in comparison to zopicl one. Expand
Discriminative stimulus properties of benzodiazepines, barbiturates and pharmacologically related drugs; relation to some intrinsic and anticonvulsant effects.
TLDR
It was found that the discriminative stimulus properties of benzodiazepines, barbiturates, and related compounds correlate with the ability of these drugs to induce ataxia, as well as with part of their anticonvulsant activity. Expand
Opioids: Similarity between evaluations of subjective effects and animal self‐administration results
TLDR
Good concordance between the human and animal results further validates each procedure and suggests the possibility that both thehuman and animal procedures are measuring a common underlying pharmacological property which relates to abuse potential of drugs. Expand
Demonstration of tolerance to and physical dependence of N-allylnormorphine (nalorphine).
TLDR
The studies provide additional support for the hypothesis that the narcotic antagonists produce a type of physical dependence that is qualitatively different from that produced by the narcotics analgesics. Expand
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