Relative abuse liability of diazepam and oxazepam: Behavioral and subjective dose effects

  title={Relative abuse liability of diazepam and oxazepam: Behavioral and subjective dose effects},
  author={Roland R. Griffiths and D R Mcleod and George E. Bigelow and Ira A. Liebson and John D. Roache},
The effects of diazepam (10–160 mg) and oxazepam (30–480 mg) were studied in volunteers with histories of drug abuse. Oral doses were administered every third day under double-blind and counterbalanced conditions. Dose-effects with area under the time-action curve data (AUC) showed diazepam to be 2.6-5.7-times more potent than oxazepam on various psychomotor, cognitive, staff-rated, and subjective measures. Comparison of relative potencies showed diazepam to be relatively more potent in… CONTINUE READING

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