Relative abundance of selenoprotein P isoforms in human plasma depends on genotype, se intake, and cancer status.

@article{Mplan2009RelativeAO,
  title={Relative abundance of selenoprotein P isoforms in human plasma depends on genotype, se intake, and cancer status.},
  author={Catherine M{\'e}plan and Fergus Nicol and Brian T Burtle and L. Katie Crosley and J Richard Arthur and John C. Mathers and John E. Hesketh},
  journal={Antioxidants & redox signaling},
  year={2009},
  volume={11 11},
  pages={2631-40}
}
Selenium (Se), a dietary trace metal essential for human health, is incorporated into selenoproteins as selenocysteine. Selenoprotein P (SePP), the major plasma selenoprotein, has both transport and antioxidant functions. In humans, it exists in plasma as two isoforms of approximately 50 and 60 kDa. This study investigated the effect of polymorphisms in the SEPP-1 gene, Se supplementation, and disease status on the proportions of SePP plasma isoforms. SePP was isolated from plasma from healthy… CONTINUE READING