Relative Toxicity of Selective Serotonin Reuptake Inhibitors (SSRIs) in Overdose

  title={Relative Toxicity of Selective Serotonin Reuptake Inhibitors (SSRIs) in Overdose},
  author={G. Isbister and S. Bowe and A. Dawson and I. Whyte},
  journal={Journal of Toxicology: Clinical Toxicology},
  pages={277 - 285}
  • G. Isbister, S. Bowe, +1 author I. Whyte
  • Published 2004
  • Medicine
  • Journal of Toxicology: Clinical Toxicology
  • Background: Selective serotonin reuptake inhibitors (SSRIs) have increasingly replaced tricyclic antidepressants (TCAs) in the treatment of depression. They appear to be safer in overdose, but there is little information on their spectrum of toxicity in overdose, or relative toxicity of each agent. Objective: To determine the effect of SSRIs in overdose, as a group, and the relative toxicity of five different SSRIs. Methods: A review of consecutive SSRI poisoning admissions to a single… CONTINUE READING
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