Relative CO(2)/NH(3) selectivities of mammalian aquaporins 0-9.

  title={Relative CO(2)/NH(3) selectivities of mammalian aquaporins 0-9.},
  author={Regine Geyer and Raif Musa-Aziz and Xue Qin and Walter F. Boron},
  journal={American journal of physiology. Cell physiology},
  volume={304 10},
Previous work showed that aquaporin 1 (AQP1), AQP4-M23, and AQP5 each has a characteristic CO(2)/NH(3) and CO(2)/H(2)O permeability ratio. The goal of the present study is to characterize AQPs 0-9, which traffic to the plasma membrane when heterologously expressed in Xenopus oocytes. We use video microscopy to compute osmotic water permeability (P(f)) and microelectrodes to record transient changes in surface pH (ΔpH(S)) caused by CO(2) or NH(3) influx. Subtracting respective values for day… CONTINUE READING