Relative Bioavailability of Rectally Administered Phenobarbital Sodium Parenteral Solution

  title={Relative Bioavailability of Rectally Administered Phenobarbital Sodium Parenteral Solution},
  author={Nina M. Graves and Gregory B. Holmes and Robert L. Kriel and Carolyn Jones-Saete and Betty Ong and David J. Ehresman},
  journal={Annals of Pharmacotherapy},
  pages={565 - 568}
Rectal administration of antiepileptic drugs may be a useful alternative route when oral administration is not possible due to illness, surgery, or status epilepticus. Although parenteral administration often replaces oral administration in these circumstances, there is not always a desirable intravenous line available or repeated intramuscular injections may not be practical. The purpose of this study was to determine the relative bioavailability and time course of absorption of the… 

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