Relationships of pyruvate and lactate during anaerobic metabolism. I. Effects of infusion of pyruvate or glucose and of hyperventilation.

  title={Relationships of pyruvate and lactate during anaerobic metabolism. I. Effects of infusion of pyruvate or glucose and of hyperventilation.},
  author={William E. Huckabee},
  journal={The Journal of clinical investigation},
  volume={37 2},
During septic shock, muscle produces lactate by way of an exaggerated NaKYadenosine triphosphatase (ATPase)Ystimulated aerobic glycolysis associated with epinephrine stimulation possibly through "2 adrenoreceptor involvement. It therefore seems logical that a proportion of hyperlactatemia in low cardiac output states would be also related to this mechanism. Thus, in low-flow and normal-to-highYflow models of shock, we investigate (1) whether muscle produces lactate and (2) whether muscle… CONTINUE READING
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