Relationships of indoleamine 2,3-dioxygenase activity and cofactors with asthma and nasal polyps.

@article{Luukkainen2014RelationshipsOI,
  title={Relationships of indoleamine 2,3-dioxygenase activity and cofactors with asthma and nasal polyps.},
  author={Annika T. Luukkainen and Jussi Karjalainen and Mikko A. Hurme and Timo Paavonen and Heini S A Huhtala and Sanna Toppila-Salmi},
  journal={American journal of rhinology & allergy},
  year={2014},
  volume={28 1},
  pages={
          e5-10
        }
}
BACKGROUND Asthma and chronic rhinosinusitis with nasal polyps (CRSwNPs) are coexisting diseases that are multifactorial. The rural environment seems to protect from atopy, but its relation with nonatopic airway inflammations has been less investigated. Indoleamine 2,3-dioxygenase (IDO) is an enzyme involved in the catabolism of the essential amino acid tryptophan (Trp) to kynurenine (Kyn). Low IDO activity has been previously observed in atopy and asthma. The objective was to investigate the… CONTINUE READING

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