Relationships between toxicity and structure of aliphatic nitriles.

  title={Relationships between toxicity and structure of aliphatic nitriles.},
  author={Frederick R Johannsen and George J. Levinskas},
  journal={Fundamental and applied toxicology : official journal of the Society of Toxicology},
  volume={7 4},
A retrospective structure-activity relationship (SAR) comparison was undertaken of several of the toxicological properties (acute and subchronic toxicity, teratogenicity, and biochemical mechanism studies) of a series of structurally similar aliphatic nitriles based on available published data. Members of this chemical class included several mononitriles (aceto-, propio-, butyro-, and acrylonitrile), dinitriles (succino- and adiponitrile), and cyanohydrin derivatives (lactonitrile and acetone… CONTINUE READING