Relationships between times to testosterone and prostate-specific antigen rises during the first off-treatment interval of intermittent androgen deprivation are prognostic for castration resistance in men with nonmetastatic prostate cancer.

@article{Kuo2015RelationshipsBT,
  title={Relationships between times to testosterone and prostate-specific antigen rises during the first off-treatment interval of intermittent androgen deprivation are prognostic for castration resistance in men with nonmetastatic prostate cancer.},
  author={Kevin F Kuo and Rachel A Hunter-Merrill and Roman Gulati and Suzanne P Hall and Teresa E Gambol and Celestia S. Higano and Evan Y Yu},
  journal={Clinical genitourinary cancer},
  year={2015},
  volume={13 1},
  pages={10-6}
}
BACKGROUND Intermittent androgen deprivation (IAD) represents an alternative to continuous AD with quality-of-life benefit and no evidence of inferior overall survival for nonmetastatic prostate cancer. Early markers of prognosis for men treated with IAD have not been described. PATIENTS AND METHODS Men with nonmetastatic prostate cancer were treated with 9 months of leuprolide and flutamide followed by a variable off-treatment interval; AD was resumed when prostate specific antigen (PSA… CONTINUE READING
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