Relationships between the structure of taxol analogues and their antimitotic activity.

@article{GUERITTEVOEGELEIN1991RelationshipsBT,
  title={Relationships between the structure of taxol analogues and their antimitotic activity.},
  author={FRANCOISE GUERITTE-VOEGELEIN and Daniel Gu{\'e}nard and François Lavelle and M T Le Goff and L Mangatal and Pierre Potier},
  journal={Journal of medicinal chemistry},
  year={1991},
  volume={34 3},
  pages={992-8}
}
A variety of synthetic analogues of taxol, a naturally occurring antitumor diterpene, were examined for their potency to inhibit microtubule disassembly. For some of the compounds, the in vitro cytotoxic properties showed a good correlation with the tubulin assay. This structure-activity relationship study shows that inhibition of microtubule disassembly is quite sensitive to the configuration at C-2' and C-3'. A correlation between the conformation of the side chain at C-13 and the activity is… CONTINUE READING