Relationships between the structure of 6-allyl-6,8-diazabicyclo[3.2.2]nonane derivatives and their sigma receptor affinity and cytotoxic activity.

@article{Holl2009RelationshipsBT,
  title={Relationships between the structure of 6-allyl-6,8-diazabicyclo[3.2.2]nonane derivatives and their sigma receptor affinity and cytotoxic activity.},
  author={Ralph Holl and Dirk Schepmann and Renate Gruenert and Patrick J. Bednarski and Bernhard W{\"u}nsch},
  journal={Bioorganic & medicinal chemistry},
  year={2009},
  volume={17 2},
  pages={777-93}
}
A series of bridged piperazine derivatives was prepared and the affinity toward sigma(1) and sigma(2) receptors by means of radioligand binding assays as well as the inhibition of the growth of six human tumor cell lines was investigated. All possible stereoisomers of the 2-hydroxy, 2-methoxy, 2,2-dimethoxy, 2-oxo, and 2-unsubstituted 6,8-diazabicyclo[3.2.2… CONTINUE READING