Relationships between sinus rhythm, treatment, and survival in the Atrial Fibrillation Follow-Up Investigation of Rhythm Management (AFFIRM) Study.

@article{Corley2004RelationshipsBS,
  title={Relationships between sinus rhythm, treatment, and survival in the Atrial Fibrillation Follow-Up Investigation of Rhythm Management (AFFIRM) Study.},
  author={Scott D. Corley and Andrew E. Epstein and John P. Dimarco and Michael J. Domanski and Nancy L. Geller and Harry L. Greene and Richard A. Josephson and Joyce C. Kellen and Richard C. Klein and Andrew Krahn and Mary Mickel and L. Brent Mitchell and Joy Dalquist Nelson and Yves D Rosenberg and Eleanor B Schron and Lynn R Shemanski and Albert L. Waldo and D. George Wyse},
  journal={Circulation},
  year={2004},
  volume={109 12},
  pages={
          1509-13
        }
}
BACKGROUND The AFFIRM Study showed that treatment of patients with atrial fibrillation and a high risk for stroke or death with a rhythm-control strategy offered no survival advantage over a rate-control strategy in an intention-to-treat analysis. This article reports an "on-treatment" analysis of the relationship of survival to cardiac rhythm and treatment as they changed over time. METHODS AND RESULTS Modeling techniques were used to determine the relationships among survival, baseline… CONTINUE READING

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