Relationships between regional neuronal loss and neurofibrillary changes in the hippocampal formation and duration and severity of Alzheimer disease.

@article{Wegiel1997RelationshipsBR,
  title={Relationships between regional neuronal loss and neurofibrillary changes in the hippocampal formation and duration and severity of Alzheimer disease.},
  author={Jarek Wegiel and Michal Tarnawski and Matthew Bobinski and Barry Reisberg and Mony J de Leon and Douglas Craig Miller and Henryk M. Wiśniewski},
  journal={Journal of neuropathology and experimental neurology},
  year={1997},
  volume={56 4},
  pages={414-20}
}
The total numbers of neurons with and without neurofibrillary changes in the hippocampal subdivisions were estimated in 16 subjects with Alzheimer disease (AD) and in 5 normal elderly controls. On the basis of clinical symptoms, AD patients were subdivided into relatively less (AD-1. Functional Assessment Staging [FAST] stages 7a to 7c) and more severely affected (AD-2, FAST stages 7e to 7f) patient groups. In the AD-1 group relative to controls, the total number of neurons was reduced only in… CONTINUE READING

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