Relationships between plasma insulin-like growth factor-I and insulin-like growth factor binding protein-3 and second breast cancer risk in a prevention trial of fenretinide.

@article{Decensi2003RelationshipsBP,
  title={Relationships between plasma insulin-like growth factor-I and insulin-like growth factor binding protein-3 and second breast cancer risk in a prevention trial of fenretinide.},
  author={Andrea U. Decensi and Umberto Veronesi and Rosalba Miceli and Harriet Johansson and Luigi Mariani and Tiziana Camerini and Maria Gaetana Di Mauro and Elena Cavadini and Giuseppe De Palo and Alberto Costa and Marjorie Perloff and Winfred F. Malone and Franca Formelli},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2003},
  volume={9 13},
  pages={4722-9}
}
PURPOSE High circulating insulin-like growth factor (IGF) -I and/or low IGF-binding protein (IGFBP) -3 levels are associated with increased breast cancer risk in unaffected premenopausal women. We determined whether IGF-I and IGFBP-3 predict second breast cancer risk, and whether their changes during fenretinide explain observed reductions in second breast cancer in women </=50 years of age. EXPERIMENTAL DESIGN Within a Phase III trial, we measured baseline and 1-year levels of IGF-I, IGFBP-3… CONTINUE READING
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Randomized trial of fenretinide to prevent second breast malignancy in women with early breast cancer

  • U. Veronesi, G. De Palo, +18 authors M. B. Sporn
  • J. Natl. Cancer Inst.,
  • 1999
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