Relationships between hippocampal atrophy, white matter disruption, and gray matter hypometabolism in Alzheimer's disease.

@article{Villain2008RelationshipsBH,
  title={Relationships between hippocampal atrophy, white matter disruption, and gray matter hypometabolism in Alzheimer's disease.},
  author={Nicolas Villain and B{\'e}atrice Desgranges and Fausto Viader and Vincent de La Sayette and Florence M{\'e}zenge and Brigitte Landeau and Jean-Claude Baron and Francis Eustache and Ga{\"e}l Ch{\'e}telat},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2008},
  volume={28 24},
  pages={6174-81}
}
In early Alzheimer's disease (AD), the hippocampal region is the area most severely affected by cellular and structural alterations, yet glucose hypometabolism predominates in the posterior association cortex and posterior cingulate gyrus. One prevalent hypothesis to account for this discrepancy is that posterior cingulate hypometabolism results from disconnection from the hippocampus through disruption of the cingulum bundle. However, only partial and indirect evidence currently supports this… CONTINUE READING
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