Relationships between factor VIII:Ag and factor VIII in recombinant and plasma-derived factor VIII concentrates.

@article{Lin2004RelationshipsBF,
  title={Relationships between factor VIII:Ag and factor VIII in recombinant and plasma-derived factor VIII concentrates.},
  author={Y Lin and Xueqiu Yang and M Ch{\'e}vrier and Sharon Craven and Trevor W. Barrowcliffe and R{\'e}al Lemieux and Frederick A. Ofosu},
  journal={Haemophilia : the official journal of the World Federation of Hemophilia},
  year={2004},
  volume={10 5},
  pages={
          459-69
        }
}
A variety of plasma-derived (pd) and recombinant (r) factor VIII (FVIII) concentrates are used to prevent and treat bleeding in severe hemophilia A patients. A significant side effect of FVIII replacement is the development of FVIII neutralizing antibodies (inhibitors) in up to 30% of patients receiving FVIII concentrates. The FVIII protein content (FVIII:Ag) per unit of FVIII:C in FVIII concentrates, and how effectively the FVIII:Ag in FVIII concentrates binds to von Willebrand factor (VWF… CONTINUE READING

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