Relationships between eosinophilic inflammation, tissue remodeling, and fibrosis in eosinophilic esophagitis.

  title={Relationships between eosinophilic inflammation, tissue remodeling, and fibrosis in eosinophilic esophagitis.},
  author={Seema S. Aceves and S. J. Ackerman},
  journal={Immunology and allergy clinics of North America},
  volume={29 1},
  pages={197-211, xiii-xiv}
The clinical and pathologic features of eosinophilic esophagitis (EE) include extensive tissue remodeling. Increasing evidence supports a key role for the eosinophil in multiple aspects of the esophageal remodeling and fibrosis seen in this allergic disease. This article reviews the clinical implications of esophageal remodeling and fibrosis in EE and discusses the possible pathogenic mechanisms inducing and regulating these responses. The focus is specifically on eosinophil and cytokine… CONTINUE READING

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