Relationships between default-mode network connectivity, medial temporal lobe structure, and age-related memory deficits

@article{Ward2015RelationshipsBD,
  title={Relationships between default-mode network connectivity, medial temporal lobe structure, and age-related memory deficits},
  author={Andrew M. Ward and Elizabeth C. Mormino and Willem Huijbers and Aaron P. Schultz and Reisa A. Sperling},
  journal={Neurobiology of Aging},
  year={2015},
  volume={36},
  pages={265-272}
}
Advanced aging negatively impacts memory performance. Brain aging has been associated with shrinkage in medial temporal lobe structures essential for memory--including hippocampus and entorhinal cortex--and with deficits in default-mode network connectivity. Yet, whether and how these imaging markers are relevant to age-related memory deficits remains a topic of debate. Using a sample of 182 older (age 74.6 ± 6.2 years) and 66 young (age 22.2 ± 3.6 years) participants, this study examined… CONTINUE READING

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