Relationships between common polymorphisms of adenosine triphosphate-binding cassette transporter A1 and high-density lipoprotein cholesterol and coronary heart disease in a population with type 2 diabetes mellitus.

@article{PorchayBaldrelli2009RelationshipsBC,
  title={Relationships between common polymorphisms of adenosine triphosphate-binding cassette transporter A1 and high-density lipoprotein cholesterol and coronary heart disease in a population with type 2 diabetes mellitus.},
  author={Isabelle Porchay-Bald{\'e}relli and F. P{\'e}an and N. Emery and S. Maimaitiming and N. Bellili and F. Travert and K. Mohammedi and R. Roussel and M. Marre and F. Fumeron},
  journal={Metabolism: clinical and experimental},
  year={2009},
  volume={58 1},
  pages={
          74-9
        }
}
  • Isabelle Porchay-Baldérelli, F. Péan, +7 authors F. Fumeron
  • Published 2009
  • Medicine
  • Metabolism: clinical and experimental
  • Patients with type 2 diabetes mellitus (T2D) have a high coronary risk partly because of low levels of high-density lipoprotein-cholesterol (HDL-C). The adenosine triphosphate-binding cassette transporter A1 (ABCA1) plays a key role in HDL metabolism. We studied the association of common single nucleotide polymorphisms (SNPs) in the ABCA1 gene with HDL-C levels and coronary risk in a cohort of subjects with T2D. We studied 5 SNPs: +69C>T, +378G>C, R219K, I883M, and R1587K. The C allele of +378G… CONTINUE READING
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