Relationships between cobalamin, epidermal growth factor, and normal prions in the myelin maintenance of central nervous system.


Cobalamin (Cbl), epidermal growth factor (EGF), and prions (PrPs) are key molecules for myelin maintenance in the central and peripheral nervous systems. Cbl and EGF increase normal prion (PrP(C)) synthesis and PrP(C) levels in rat spinal cord (SC) and elsewhere. Cbl deficiency increases PrP(C) levels in rat SC and cerebrospinal fluid (CSF), and decreases… (More)
DOI: 10.1016/j.biocel.2014.09.011


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