Relationships between beta- and alpha2-adrenoceptors and G coupling proteins in the human brain: effects of age and suicide.

@article{Sastre2001RelationshipsBB,
  title={Relationships between beta- and alpha2-adrenoceptors and G coupling proteins in the human brain: effects of age and suicide.},
  author={Magdalena Sastre and Jos{\'e} Guim{\'o}n and Jes{\'u}s Andr{\'e}s Garc{\'i}a-Sevilla},
  journal={Brain research},
  year={2001},
  volume={898 2},
  pages={242-55}
}
Interactions between brain alpha2- and beta-adrenoceptors are of interest in physiological (aging) and pathological (major depression) processes involving both receptors. In this study, total beta-adrenoceptors and beta1/2-subtypes were quantitated in postmortem human brains to investigate their relationships with alpha2A-adrenoceptors and specific G proteins during the process of aging and in brains of suicide victims. Analysis of [3H]CGP12177 binding, in the presence of CGP20712A (beta1… CONTINUE READING

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