Relationships between age-dependent changes in the effect of almitrine on H(+)-ATPase/ATPsynthase and the pattern of membrane fatty acid composition.

@article{JumelleLaclau1993RelationshipsBA,
  title={Relationships between age-dependent changes in the effect of almitrine on H(+)-ATPase/ATPsynthase and the pattern of membrane fatty acid composition.},
  author={M. Jumelle-Laclau and M. Rigoulet and N. Av{\'e}ret and X. Leverve and L. Dubourg and A. Carbonneau and M. Clerc and B. Gu{\'e}rin},
  journal={Biochimica et biophysica acta},
  year={1993},
  volume={1141 1},
  pages={
          90-4
        }
}
The effects of almitrine on ATPase/ATPsynthase previously described in beef heart mitochondria (Rigoulet et al. (1990) Biochim. Biophys. Acta 1018, 91-97) are also observed in liver mitochondria isolated from rats older than 7 weeks. In contrast, in rats younger than 5 weeks, almitrine at the same concentration has no effect on the ATPase/ATPsynthase complex. This age-dependent action of almitrine is well correlated with age-dependent modifications of two fatty acids: linoleic and… Expand
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