Relationships between Mucosal Antibodies, Non-Typeable Haemophilus influenzae (NTHi) Infection and Airway Inflammation in COPD

@inproceedings{Staples2016RelationshipsBM,
  title={Relationships between Mucosal Antibodies, Non-Typeable Haemophilus influenzae (NTHi) Infection and Airway Inflammation in COPD},
  author={Karl J Staples and Stephen Charles Taylor and Steve Thomas and Stephanie Leung and Karen Cox and Thierry G. Pascal and Kristoffer K Ostridge and Lindsay Welch and Andrew C. Tuck and Stuart C Clarke and Andrew R. Gorringe and T Wilkinson},
  booktitle={PloS one},
  year={2016}
}
Non-typeable Haemophilus influenzae (NTHi) is a key pathogen in COPD, being associated with airway inflammation and risk of exacerbation. Why some patients are susceptible to colonisation is not understood. We hypothesised that this susceptibility may be due to a deficiency in mucosal humoral immunity. The aim of our study (NCT01701869) was to quantify the amount and specificity of antibodies against NTHi in the lungs and the associated risk of infection and inflammation in health and COPD… CONTINUE READING
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