Relationships among murine CD11c(high) dendritic cell subsets as revealed by baseline gene expression patterns.

@article{Edwards2003RelationshipsAM,
  title={Relationships among murine CD11c(high) dendritic cell subsets as revealed by baseline gene expression patterns.},
  author={Alexander D Edwards and Damien Chaussabel and Simon Tomlinson and Oliver Schulz and Alan Sher and Caetano Reis e Sousa},
  journal={Journal of immunology},
  year={2003},
  volume={171 1},
  pages={47-60}
}
The functional relationships and properties of different subtypes of dendritic cells (DC) remain largely undefined. To better characterize these cells, we used global gene analysis to determine gene expression patterns among murine CD11c(high) DC subsets. CD4(+), CD8alpha(+), and CD8alpha(-) CD4(-) (double negative (DN)) DC were purified from spleens of normal C57/BL6 mice and analyzed using Affymetrix microarrays. The CD4(+) and CD8alpha(+) DC subsets showed distinct basal expression profiles… CONTINUE READING

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