Relationships Among Ventral Striatal Dopamine Release, Cortisol Secretion, and Subjective Responses to Amphetamine

  title={Relationships Among Ventral Striatal Dopamine Release, Cortisol Secretion, and Subjective Responses to Amphetamine},
  author={L. Oswald and D. Wong and M. McCaul and Yun Zhou and H. Kuwabara and L. Choi and J. Bra{\vs}i{\'c} and G. Wand},
  • L. Oswald, D. Wong, +5 authors G. Wand
  • Published 2005
  • Medicine
  • Neuropsychopharmacology
  • There is evidence that stress and glucocorticoids alter drug self-administration and mesolimbic dopamine (DA) activity in preclinical models. The primary purpose of this study was to test the hypothesis that glucocorticoids are associated with psychostimulant reinforcement and DA release in humans. In total, 16 healthy adults, ages 18–27 years, underwent two consecutive 90-min PET studies with high specific activity [11C]raclopride. The first scan was preceded by intravenous saline, and the… CONTINUE READING
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