Relationship of topical dose and percutaneous absorption in rhesus monkey and man.

@article{Wester1976RelationshipOT,
  title={Relationship of topical dose and percutaneous absorption in rhesus monkey and man.},
  author={Ronald C. Wester and Howard Ira Maibach},
  journal={The Journal of investigative dermatology},
  year={1976},
  volume={67 4},
  pages={518-20}
}
[14C]Testosterone, [14C]hydrocortisone, and [14C]benzoic acid were applied to skin of the rhesus monkey and man, and percutaneous absorption was quantitated by measuring urinary excretion of 14C. In the rhesus, the concentration of testosterone was increased from 4 to 4000 mug/cm2 in 5 steps. The efficiency of absorption decreased from 18.4 +/- 9.5% to 1.4 +/- 0.8%. However, the total compound absorbed (per cm2 area) always increased, from a low of 0.7mug to 56 mug. In man, testosterone… CONTINUE READING

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