Relationship of the notochord to foregut development in the fetal rat model of esophageal atresia.

@article{Qi1999RelationshipOT,
  title={Relationship of the notochord to foregut development in the fetal rat model of esophageal atresia.},
  author={Bao Quan Qi and Spencer W Beasley},
  journal={Journal of pediatric surgery},
  year={1999},
  volume={34 11},
  pages={
          1593-8
        }
}
BACKGROUND/PURPOSE The notochord (Nt) is thought to act as a primary organizer for adjacent axial embryonic organs. The current study used the Adriamycin-induced fetal rat model of esophageal atresia and tracheoesophageal fistula (EA-TEF) to determine whether anomalies of the foregut (FG) were associated with an abnormal Nt. METHODS Eight experimental female Sprague-Dawley rats received intraperitoneal injection of Adriamycin (1.75 mg/kg) on gestational days 6 to 9 inclusive, and 4 control… CONTINUE READING
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