Relationship of the K-ras/c-mos expression patterns with angiogenesis in non-small cell lung carcinomas.

@article{Zacharatos2001RelationshipOT,
  title={Relationship of the K-ras/c-mos expression patterns with angiogenesis in non-small cell lung carcinomas.},
  author={Panayotis Zacharatos and Athanassios Kotsinas and Petros Tsantoulis and Kostas Evangelou and Dimitris Kletsas and Panayiotis J. Asimacopoulos and Ipatia A. Doussis-Anagnostopoulou and F. Pezzella and Kevin C. Gatter and Athanasios G. Papavassiliou and Christos N. Kittas and Vassilis G Gorgoulis},
  journal={Molecular medicine},
  year={2001},
  volume={7 9},
  pages={
          590-7
        }
}
BACKGROUND Neo-angiogenesis is an acquired capability vital for a tumor to grow and metastasize. Evidence has shown that the mitogen-activated protein (MAP) kinase pathway is involved in this process. Alterations of K-ras and c-mos, two pivotal components of this pathway, have been implicated in non-small cell lung carcinogenesis. In the present report, we examine, in a series of non-small cell lung carcinomas (NSCLCs), the status of K-ras and c-mos oncoproteins in correlation with the tumor… CONTINUE READING
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