Relationship of serotonin transporter gene polymorphisms and haplotypes to mRNA transcription.

@article{Bradley2005RelationshipOS,
  title={Relationship of serotonin transporter gene polymorphisms and haplotypes to mRNA transcription.},
  author={Sarah L Bradley and Katerina Dodelzon and Harinder K Sandhu and Robert A Philibert},
  journal={American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics},
  year={2005},
  volume={136B 1},
  pages={
          58-61
        }
}
The serotonin transporter (5HTT; chromosomal location 17q12) is an important regulator of serotonergic neurotransmission and is the site of action for a number of antidepressant medications. Sequence variation at a VNTR known as the 5HTTLPR, which is 1.4 kb upstream of the translation start of 5HTT, has been associated in some studies with increased vulnerability to depression, neuroticism, and autism. Support for these clinical observations has included laboratory findings that 5HTTLPR… CONTINUE READING

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Serotonin transporter mRNA levels are associated with the methylation of an upstream CpG island.

  • American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • 2007
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