Relationship of pleconaril susceptibility and clinical outcomes in treatment of common colds caused by rhinoviruses.

@article{Pevear2005RelationshipOP,
  title={Relationship of pleconaril susceptibility and clinical outcomes in treatment of common colds caused by rhinoviruses.},
  author={Daniel C Pevear and Frederick G. Hayden and Tina M Demenczuk and Linda R. Barone and Mark A. McKinlay and Marc S. Collett},
  journal={Antimicrobial agents and chemotherapy},
  year={2005},
  volume={49 11},
  pages={4492-9}
}
Pleconaril, a specific inhibitor of human picornaviruses, showed therapeutic efficacy against community-acquired colds caused by rhinoviruses in two placebo-controlled trials. Virological assessments were conducted during these trails, including virus culture and drug susceptibility testing. Nasal mucus samples collected from the enrolled patients were tested for the presence of picornavirus by reverse transcriptase PCR and culture. In total, 827 baseline nasal mucus samples were positive by… CONTINUE READING

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