Relationship of plasminogen activator inhibitor 1 gene 4G/5G polymorphisms to hypertension in Korean women.

@article{Kim2012RelationshipOP,
  title={Relationship of plasminogen activator inhibitor 1 gene 4G/5G polymorphisms to hypertension in Korean women.},
  author={Kyu Nam Kim and Kwang-min Kim and Bom-taeck Kim and Nam-seok Joo and Doo-Yeoun Cho and Duck-joo Lee},
  journal={Chinese medical journal},
  year={2012},
  volume={125 7},
  pages={1249-53}
}
BACKGROUND Hypertension (HTN) is a major determinant of various cardiovascular events. Plasma levels of plasminogen activator inhibitor 1 (PAI-1) modulate this risk. A deletion/insertion polymorphism within the PAI-1 loci (4G/4G, 4G/5G, 5G/5G) affects the expression of this gene. The present study investigated the association between PAI-1 loci polymorphisms and HTN in Korean women. METHODS Korean women (n = 1312) were enrolled in this study to evaluate the association between PAI-1 4G/5G… CONTINUE READING