Relationship of orthostatic blood pressure to white matter hyperintensities and subcortical volumes in late-life depression.

@article{Colloby2011RelationshipOO,
  title={Relationship of orthostatic blood pressure to white matter hyperintensities and subcortical volumes in late-life depression.},
  author={Sean J. Colloby and Akshya Vasudev and John T. O'Brien and Michael J. Firbank and Steve W. Parry and Alan J Thomas},
  journal={The British journal of psychiatry : the journal of mental science},
  year={2011},
  volume={199 5},
  pages={
          404-10
        }
}
BACKGROUND Structural brain abnormalities are associated with late-life major depression, with numerous studies reporting increased white matter hyperintensities (WMH) and reduced cortical/subcortical grey matter volumes. There is strong evidence linking vascular disease to WMH, but limited evidence on its association with subcortical volumes. AIMS To investigate the relationship of orthostatic blood pressure changes to WMH and subcortical grey matter volumes in late-life depression. METHOD… CONTINUE READING
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