Relationship of microvascular disease in diabetes to metabolic control.

@article{Engerman1977RelationshipOM,
  title={Relationship of microvascular disease in diabetes to metabolic control.},
  author={Ronald L. Engerman and J. M. B. Bloodworth and Stuart Nelson},
  journal={Diabetes},
  year={1977},
  volume={26 8},
  pages={760-9}
}
Dogs were made alloxan-diabetic and randomly distributed into either of two prospective treatment groups. In one group it was intended that the metabolic signs of diabetes be controlled poorly, and commercial insulin was administered in doses inadequate to prevent chronic, severe hyperglycemia and glucosuria. In the other group it was intended that the metabolic disorder be well controlled, and the animals received food and commercial insulin twice daily such that the hyperglycemia and… CONTINUE READING

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