Relationship of lithium chloride dose to treatment response in acute mania.

@article{Stokes1976RelationshipOL,
  title={Relationship of lithium chloride dose to treatment response in acute mania.},
  author={Peter E. Stokes and James Howard Kocsis and O J Arcuni},
  journal={Archives of general psychiatry},
  year={1976},
  volume={33 9},
  pages={1080-4}
}
Three separate lithium chloride doses, calculated according to body weight, and a placebo were administered under double-blind conditions to 68 manic inpatients. The relationship of lithium chloride treatment dose to steady-state serum lithium levels (day 7 to 10 of treatment) and clinical response were examined. High (0.72 mEq/kg/day) and medium (0.5 mEq/kg/day) lithium chloride doses were more efficacious than placebo (P<.001 and P<.05, respectively), as determined by decrements in global… CONTINUE READING

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