Relationship of inositol phospholipid metabolism to phospholipase A2.


The mechanism by which agonists stimulate phospholipase A2 of platelets is still much of a mystery. We have presented a discussion that suggests that neither Ca2+, protein kinase C or dissociation of the inhibitory GTP-binding protein Gi is solely responsible for activating this enzyme. We cannot exclude the possibility that there may be some contribution… (More)


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