Relationship of hypoxia-inducible factor 1α and p21WAF1/CIP1 expression to cell apoptosis and clinical outcome in patients with gastric cancer

Abstract

BACKGROUND Hypoxia-inducible factor-1alpha (HIF-1alpha) plays an essential role in oxygen homeostasis. The expression of HIF-1alpha-inducible genes is associated with tumor progression. p21 mediates cell cycle arrest and is one of the downstream genes targeted by HIF-1. PATIENTS AND METHODS We examined the relationship between HIF-1alpha and p21… (More)

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@article{Mizokami2006RelationshipOH, title={Relationship of hypoxia-inducible factor 1α and p21WAF1/CIP1 expression to cell apoptosis and clinical outcome in patients with gastric cancer}, author={Ken Mizokami and Yoshihiro Kakeji and Shinya Oda and Yoshihiko Maehara}, journal={World Journal of Surgical Oncology}, year={2006}, volume={4}, pages={94 - 94} }