Relationship of family cancer history to the expression of p53, p21WAF-1, HER-2/neu, and K-ras mutation in pancreatic adenocarcinoma.

@article{Dergham1997RelationshipOF,
  title={Relationship of family cancer history to the expression of p53, p21WAF-1, HER-2/neu, and K-ras mutation in pancreatic adenocarcinoma.},
  author={Sanaa T Dergham and Matthew C Dugan and Patricia Arlauskas and Wei Du and Vainutis K. Vaitkevicius and John D. Crissman and Fazlul H. Sarkar},
  journal={International journal of pancreatology : official journal of the International Association of Pancreatology},
  year={1997},
  volume={21 3},
  pages={225-34}
}
CONCLUSION In our series of 81 cases, a history of family cancer was present in 52% of patients (42/81) with pancreatic cancer. Nine percent (7/81)had a family history of pancreatic cancer. Our studies suggest a possible relationship of family cancer history to the expression of p53 and p21WAF in pancreatic tumors, but show no relationship to the expression of HER-2/neu or to the prevalence of K-ras mutations. A lower incidence of p53 expression observed in patients with a family history of… CONTINUE READING
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