Relationship of eNOS gene variants to diseases that have in common an endothelial cell dysfunction

@article{Heltianu2005RelationshipOE,
  title={Relationship of eNOS gene variants to diseases that have in common an endothelial cell dysfunction},
  author={C. Heltianu and G. Costache and A. Gafencu and M. Diaconu and Mihaela Bodeanu and C. Cristea and K. Azibi and L. Poenaru and M. Simionescu},
  journal={Journal of Cellular and Molecular Medicine},
  year={2005},
  volume={9}
}
The endothelial cell (EC) dysfunction is a common characteristic of various pathologies that include atherosclerosis, hypertension, and Fabry's disease. Aware of the role of eNO and ACE in EC dysfunction, we questioned whether polymorphism of eNOS and/or ACE gene may be a common denominator in these pathologies. Patients with CHD (108), HT (109), Fabry's disease (37) and healthy subjects (control, 141) were genotyped for the eNOSG894T by RFLP‐PCR technique and for eNOS4b/a, and ACEI/D… Expand
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TLDR
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eNOS gene Glu298Asp and 4b/a polymorphisms are associated with renal function parameters in Mexican patients with Fabry disease.
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The results suggest that eNOS polymorphisms may be an additional risk factor in development of ACS. Expand
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TLDR
Findings suggest that the G894T polymorphism of the eNOS gene was not associated with CAD in Chilean individuals. Expand
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TLDR
It is suggested that the 4a4b polymorphism of the NOS3 gene was associated with MI in Tunisian patients, according to the models considered. Expand
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Using these variants in predictive testing is unlikely to be useful, although the population attributable fraction could be substantial if the modest associations are causal, and the need for large-scale genetic association studies using tagging polymorphisms is warranted. Expand
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An Updated Meta-Analysis of Endothelial Nitric Oxide Synthase Gene: Three Well-Characterized Polymorphisms with Hypertension
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The role of eNOS G894T and 4b/a polymorphisms on hypertension in Asians, and T−786C polymorphism in Whites is ascertained via a comprehensive meta-analysis. Expand
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