Relationship of cortical atrophy to fatigue in patients with multiple sclerosis.

@article{Pellicano2010RelationshipOC,
  title={Relationship of cortical atrophy to fatigue in patients with multiple sclerosis.},
  author={Clelia Pellicano and Antonio Gallo and Xiaobai Li and Vasiliki N. Ikonomidou and Iordanis E. Evangelou and Joan Ohayon and Susan K. Stern and Mary E Ehrmantraut and Fredric K. Cantor and Henry F. McFarland and Francesca R Bagnato},
  journal={Archives of neurology},
  year={2010},
  volume={67 4},
  pages={447-53}
}
BACKGROUND Fatigue is a common and disabling symptom of multiple sclerosis (MS). Previous studies reported that damage of the corticostriatothalamocortical circuit is critical in its occurrence. OBJECTIVE To investigate the relationship between fatigue in MS and regional cortical and subcortical gray matter atrophy. DESIGN Case-control study. SETTING National Institutes of Health. PARTICIPANTS Twenty-four patients with MS and 24 matched healthy volunteers who underwent 3.0-T magnetic… CONTINUE READING
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