Relationship of circulating tumor cells to tumor response, progression-free survival, and overall survival in patients with metastatic colorectal cancer.

@article{Cohen2008RelationshipOC,
  title={Relationship of circulating tumor cells to tumor response, progression-free survival, and overall survival in patients with metastatic colorectal cancer.},
  author={Steven J. Cohen and Cornelis J A Punt and Nicholas O Iannotti and Bruce H Saidman and Kert D. Sabbath and Nashat Y. Gabrail and Joel Picus and Michael Morse and Edith Mitchell and Merrill Miller and Geraldine Doyle and H. A. Tissing and Leon W. M. M. Terstappen and Neal J. Meropol},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2008},
  volume={26 19},
  pages={
          3213-21
        }
}
PURPOSE As treatment options expand for metastatic colorectal cancer (mCRC), a blood marker with a prognostic and predictive role could guide treatment. We tested the hypothesis that circulating tumor cells (CTCs) could predict clinical outcome in patients with mCRC. PATIENTS AND METHODS In a prospective multicenter study, CTCs were enumerated in the peripheral blood of 430 patients with mCRC at baseline and after starting first-, second-, or third-line therapy. CTCs were measured using an… CONTINUE READING

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