Relationship of cannabinoid CB1 receptor and cholecystokinin immunoreactivity in monkey dorsolateral prefrontal cortex.

@article{Eggan2010RelationshipOC,
  title={Relationship of cannabinoid CB1 receptor and cholecystokinin immunoreactivity in monkey dorsolateral prefrontal cortex.},
  author={Stephen Eggan and Darlene S. Melchitzky and Susan R. Sesack and Kenneth N. Fish and David A. Lewis},
  journal={Neuroscience},
  year={2010},
  volume={169 4},
  pages={1651-61}
}
Exposure to cannabis impairs cognitive functions reliant on the circuitry of the dorsolateral prefrontal cortex (DLPFC) and increases the risk of schizophrenia. The actions of cannabis are mediated via the brain cannabinoid 1 receptor (CB1R), which in rodents is heavily localized to the axon terminals of cortical GABA basket neurons that contain cholecystokinin (CCK). Differences in the laminar distribution of CB1R-immunoreactive (IR) axons have been reported between rodent and monkey neocortex… CONTINUE READING

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