Relationship of brain ethanol metabolism to the hypnotic effect of ethanol. II: Studies in selectively bred rats and mice.

@article{Zimatkin2001RelationshipOB,
  title={Relationship of brain ethanol metabolism to the hypnotic effect of ethanol. II: Studies in selectively bred rats and mice.},
  author={Sergey Michailovich Zimatkin and Anton V Liopo and Valentina Satanovskaya and L R Bardina And and Richard A. Deitrich},
  journal={Alcoholism, clinical and experimental research},
  year={2001},
  volume={25 7},
  pages={982-8}
}
BACKGROUND To clarify the role of brain acetaldehyde in the hypnotic effect of ethanol, we compared the ethanol-oxidizing capacity (rate of acetaldehyde accumulation) and catalase and aldehyde dehydrogenase activity in the brains of animals genetically selected for different sensitivities to the hypnotic effect of ethanol. METHODS We used high, low, or control alcohol-sensitive rats (HAS, LAS, and CAS) and short- and long-sleep mice (SS and LS), as well as SS x LS recombinant inbred mice with… CONTINUE READING