Relationship of body mass index with aromatisation and plasma and tissue oestrogen levels in postmenopausal breast cancer patients treated with aromatase inhibitors.

@article{Lnning2014RelationshipOB,
  title={Relationship of body mass index with aromatisation and plasma and tissue oestrogen levels in postmenopausal breast cancer patients treated with aromatase inhibitors.},
  author={Per Eystein L\onning and Benjamin P Haynes and Mitch Dowsett},
  journal={European journal of cancer},
  year={2014},
  volume={50 6},
  pages={1055-64}
}
BACKGROUND Recent data have raised concern about the clinical efficacy of aromatase inhibitors in overweight and/or obese breast cancer patients. We report in vivo aromatase inhibition and plasma and tissue oestrogen levels in relation to body mass index (BMI) status among breast cancer patients treated with different aromatase inhibitors. METHODS We compared data on in vivo aromatase inhibition (64 patients) as well as plasma and tissue oestrogen levels from patients participating in our… CONTINUE READING